The Nexera UC Chiral CCC column consists of a modified cellulose, including the combination of 3-chloro-4-methylphenylcarbamate and 3,5-dichlorophenylcarbamate bonding groups coated on high-purity, high performance spherical silica particles. The combination of bonded groups stabilizes the solubility of coated phase making for a durable phase similar to other widely used coated phases. The use of cellulose modified with chlorinated phenyl groups provides for separation of many previously unresolved/poorly resolved chiral mixtures.