The Velox SP-C18 is designed and intended specifically for use in LC-MS/MS applications under low pH conditions. The sterically protected ligand resists hydrolysis, resulting in increased lifetime versus a standard C18 when using strongly acidic (pH 1-3) mobile phases, and provides a balanced retention profile for multiple compound classes. Use Velox SP-C18 when low pH conditions are required to separate neutral acids, charged bases, and more. The Velox superficially porous particle (SPP) provides UHPLC-like high speed, high resolution separations to reduce run time and increase sample throughput when run on a standard HPLC system. pH range 1-8, maximum temperature 80C, maximum pressure 400 bar/40 MPa/5800 psi.