The NexLeaf CBX II for Potency is a superficially porous particle (SPP) C18 column designed for UHPLC with UV or PDA detectors, or LCMS-8030/8040/8045/8050/8060 analysis of cannabinoids in various cannabis and hemp matrices. Shimadzu NexLeaf CBX II Guard Column, 1.8 µm (220-91525-76) and holder 220-91525-73 are recommended to protect the analytical column from matrix components and prolong its lifetime.