The bioinert Scepter column has a PEEK-lined stainless steel body with a high pressure polymer frit for a completely metal-free flowpath. The organosilane hybrid particle with C18 ligand is suitable for a wide variety of applications and mobile phase conditions up to pH 12 and 100% aqueous. PLS hardware eliminates adsorption and reduces tailing for compounds that tend to form chelates with metal surfaces, especially those containing phosphate groups. USP L1, pore size: 120A, pH range: 1-12, max pressure: 100 MPa/1000 bar/14,500 psi, carbon load: 20%, fully endcapped. Phase is similar to Acquity BEH C18, PLS hardware is unique.