The bioinert Scepter column has a PEEK-lined stainless steel body with a high pressure polymer frit for a completely metal-free flowpath. The organosilane hybrid particle with diol ligand is recommended for the analysis of polar and hydrophilic compounds that have limited or no retention on alkyl phases like C8 and C18. Ideal for LCMS use since ion-pairing reagents are not required, and the high organic mobile phases result in efficient solvent evaporation for increased sensitivity. PLS hardware eliminates adsorption and reduces tailing for compounds that tend to form chelates with metal surfaces, especially those containing phosphate groups. USP L20, pore size: 120A, pH range: 2-10, max pressure: 45 MPa/450 bar/6,500 psi, 12% carbon load, non-endcapped. Phase is similar to XBridge BEH HILIC; PLS hardware is unique.